TAMI (IMI) Central R&D Inst.
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Crystallization stage in chemical processes

Crystallization

 

Many chemical processes include a crystallization stage. To obtain a specific product and a robust process, basic thermodynamic data is required, such as solubility as a function of temperature, field of crystallization of the required product and influence of the concentration of impurities. Part of this data is collected in collaboration with the Thermo-Chemistry 1 department. If required for a new process, a solid-liquid phase diagram related to the considered system can be constructed, based on chemical and XRD analyses. Collecting this data helps to define the optimum crystallization route.

The laboratory tests are carried out first in batch conditions, but if required, the tests can be carried out in conditions simulating a continuous process.

The habit and particle size distribution (PSD) of the crystals can be determined on-line with the help of the Lazantech device, and end-received particles analyzed by a Scanning Electron Microscope and a particle size distribution analyzer, both available at TAMI. To scale up the process, a pilot-scale 100 liter forced-circulation crystallizer is also available at TAMI.

A Glass and Stainless Steel column equipped with a controlled thermostat allows for the evaluation of product purification by melting crystallization at a temperature ranging from -20oC to +180oC.